Chinese-yew - blog*spot

[Abstract]

Taxus is widely known as one of the excellent drugs within cancer treatment in the latest 30 years. Because taxol’s content really micro in Chinese yew.therefore seeks taxanes compounds that can replace or may transform as the taxol hasthe necessity. Moreover, in chemistry domain along with taxanes compound medicinesource increasing, gradually regarding taxanes compound research complete synthesisby the natural products into effectively, the tolerance is better, absorbs a easier newgeneration of synonym, seeks has the better pharmacological action and the more widespread clinical practice derivative. Therefore, current besides protection wild Chineseyew resources and enhance theartificial nurture ability, pays great attention is to research not natural gain method for taxol. At present taxol is obtained by extraction andseparation,the cell raise and carries on half synthesis from baccatinⅢor10-deacetylbaccatinⅢof methods. Therefore,Seeks can synthesize and transform taxol’s origin toappear importantly.This experiment mainly is a method which unifies using the positivephase chromatograph and the opposition chromatograph, conducts the research to in the Taxus Canadensis Marsh’s matter. This article altogether is divided six chapters: First chapter willbe the understanding related Chinese yew’s history, the development present situationand the future development direction, will perform to the Chinese yew to summarize;Second chapter carrys on preliminaryly qualitative to the sample through, the thin layerchromatographic analysis comparison and the highly performance liquid chromatography empirical value,and according to the preliminary extrapolation, provides the referencefor the design sample separation flow; The third chapter is the positive phase silicagel column chromatograph to the sample separation situation. This part altogetherseparates 7 compounds, has appraised 5 compounds; The fourth chapter is that theopposition chromatograph chromatographic separates and purifies the components. Thispart mainly carries on the separation and purification to taxol and cephalomannine:The fifth chapter is the taxol which produces mellowly carries on the solvent remnantallowance the determination.The result indicates the normal hexane and the acetoneremnant allowance conforms to “ICH” safety margin. The sixth chapter is experimentalsummary.This experiment altogether obtains 9 compounds.which has appraised 7compounds.4compounds belong to the taxanes diterpenes kind of compound. This separation purifi cation technology has been applied to the taxol industrialization production.This article innovates the spot:1:separate and obtain 3-(1′, 3′-di-hydroxyacetoneyl)-butyrolactone.2.This experiment uses the positive phase silica gel chromatograph union oppositionchromatographic analysis separation purification method maybe creation more valuesfor the industrialization production taxol and its analogs.3.This experiment the method which uses the positive phase silica gel chromatographunion opposition chromatographic method for the first time in the Canadian Chineseyew’s taxanes compounds. Applies for the first time the JTY-1 opposition resin to theseparation purifies in the Canadian Chinese yew the taxusalkanes compound.

Title: Studies on the Chemical Composition in the Taxus Canadensis Marsh

Category: Cancer Letters

Filename: Studies on the Chemical Composition in the Taxus Canadensis Marsh.pdf

Pages: 174

Price: US$50.00

Buy This Paper:

Download:

Donated for this research subject:

FAVORITE: ADD TO FAVORITE

Contact: E-Mail:bizdg@126.com

                TEL:1-888-774-999A

How to get this paper's electronic documents?

1, Click the "Buy Now" button to complete the online payment

2, Download the paper's electronic document from the successful payment return page/Or the system will send this paper's electronic document to your E-Mail within 24 hours

Version:zh-cn

Perhaps You will be interested in these papers

• 2012-01-25 Study on the Expression of T-bet/GATA-3 Gene in Esophageal Carcinoma Patients and Its Interference by Immunotherapy

• 2011-12-26 Establishment of a Sandwich Elisa for Quantitative Measurement of Human High Sensitivity C-Reactive Protein and Its Primary Clinical Application

• 2011-11-07 Fundamental Study of Informatics for Pharmaceutical Analysis & Metabonomics

• 2011-11-29 Synthesis、 Antimicrobial and Anti-Tumor Activity of Thiosemicarbazones and Their Transition Metal Complexes

• 2012-01-02 The Investigation of Bladder Function after the Systematic Nerve-sparing Radical Hysterectomy

• 2011-12-11 The Effect of Nerve Growth Factor to the Breast Cancer Cell MDA-MB-231 and the Screen of Its Inhibitory Factors

• 2011-11-06 Mechanism Analysis and Experiment Study of Steep Pulse’s Antitumor Effect

• 2011-11-14 The Experimental Study and Clinical Significance of K-ras Mutations in Colorectal Cancer

• 2011-12-23 Expression of fascin Protein and E-cadherin in Oral Lichen Planus of Human

• 2011-11-15 Identification of Orosomucoid 1 as Endogenous Anti-fatigue Protein